Lyobead Production

As a result of their spherical structure, lyobeads – also known as lyophilised beads – offer a range of advantages as a lyophilised product format, including improved shelf-life and stability. To gain these benefits, companies in the diagnostics and biochemical industries are increasingly using lyobead generation for their reagents, enzymes and other biological materials. However, many of these are still developing lyobeads through manual pipetting processes, which are highly time intensive and often less precise.

Biopharma Group’s proprietary LyobeadPro™ technology both accelerates and streamlines the lyobead generation process, enabling you to unlock the benefits of using lyophilised beads while maximising time-efficiency. With its rapid, semi-automated production capability, LyobeadPro™ can generate up to 7200 highly accurate lyobeads per hour. This saves significant time, allowing your team to focus on their research and scientific work.

LyobeadPro™ also integrates seamlessly with any existing facility setup. The device’s space saving configuration makes it ideal for benchtop applications, while its plug and play design enables swift and flexible installation when compared with other solutions available.

Biopharma Group developed LyobeadPro™ by drawing on over 35 years’ experience in freeze drying. To this day, the device operates as the technological cornerstone of our own scientific team’s R&D and production operations. By investing in LyobeadPro™, you not only benefit from an advanced lyobead dispenser, but also gain access to expert technical support that continues long after purchase. 

Case Study: “Lyophilized Beads for injectables”

App Note: Optimisation and Evaluation of a Lyophilized Immunoassay in Lyobead Format

LyobeadPro™: Features and Benefits

By choosing LyobeadPro™ your operations benefit from:

• Precise, high-volume production: Generate up to 7,200 beads per hour, while ensuring accurate lyobead shape and volume – with a volume precision of 0.10% and a dispensing error rate of less than 3% CV.
• A flexible solution: LyobeadPro™ can support product sizes ranging from 5µl to 50µl. It can also accommodate single or dual nozzle operation and has easy to fit dispensing nozzles.
• Simple lyobead generation: Simplicity is at the core of the device’s design. It’s easy to read controller provides a clear count of bead numbers, and an in-built priming facility allows for simple interchange from product to product.
• Seamless integration: LyobeadPro™’s modular, benchtop design enables it to be implemented easily into any facility configuration. It can also be operated inside or outside of a nitrogen-controlled environment.
• Controlled lyobead manufacturing: The rotation of the device’s segmented LN2 dewar is carefully controlled to avoid clustering of droplets during snap freezing. The safe collection of lyobeads is then enabled by its built-in sieve container.

Here's some more info about LyobeadPRO™

Discover our App Note: "Addressing the Challenges of Lyobead Production"

Download the LyobeadPRO Benchtop Lyobead Generator Datasheet

LyobeadPRO™ FAQ's