Advanced Microscopy and Thermal Analysis for Freeze Drying Characterization
Determining critical temperatures is fundamental to the freeze drying process. Biopharma Group specialists have designed and developed three advanced analytical instruments – the Lyostat freeze-drying microscope, the Lyotherm DTA and impedance analyser and the MicroPress specifically to aid those employing freeze drying technologies within their production or research projects as well as being involved in the development of a compatible DSC imaging stage.
A rational, knowledge-based approach to designing and developing successful freeze drying formulations and cycles requires information about how the product responds to different processing conditions. Candidate formulations should be analyzed in terms of their visible physical structure, thermal characteristics and frozen state mobility, in order to gain a sufficient understanding of its behaviour throughout the freeze drying process. This ensures that cycles can be developed that are tailored to the specific needs of every product, making them efficient, safe, robust and reproducible.
With each product and process recognised as unique, by entrusting us with your project, you will benefit from our depth of experience and knowledge to ultimately reach any project goal. Each project will be carefully managed by Biopharma Group’s team of scientists and consultants. Through the operation of proprietary and advanced equipment, both R&D and manufacturing activities will run efficiently.
The latest addition to our instruments portfolio is the LyobeadPRO which is a lyobead (aka lyophilised sphere) generator that has been designed to enhance lyobead processing to meet the need for dosing material that is measured by finely adjustable controls to ensure repeatability from bead to bead.
This instrument is a freeze drying microscope (FDM) used for establishing critical events such as collapse annealing and as an aid in ensuring safe, robust, and cost-efficient cycle development. The Lyostat features real-time digital video and measurement which is achieved by using a high-performance digital USB camera to determine the exact point of collapse.The Lyostat is an integral part of the R&D and CDMO services that we offer.